On August 22, the following notable historical events related to Missouri have been recorded:

• 1804: The Lewis and Clark Expedition was near present-day Sioux City, Iowa, across from Missouri’s Atchison County, on or around August 22. They continued documenting the region’s resources and interactions with Native American tribes, advancing their exploration of the Louisiana Purchase after the recent death of Sergeant Charles Floyd.
• 1838: During the Mormon War in Missouri, tensions escalated. On or around August 22, non-Mormon vigilantes in Daviess and Carroll Counties intensified their campaign against Mormon settlers, with skirmishes contributing to the conflict that led to the Mormon expulsion order later in 1838.
• 1861: During the Civil War, the aftermath of the Battle of Wilson’s Creek (August 10) continued in Missouri. On August 22, Union forces were regrouping after their retreat from Springfield, while Confederate forces strengthened their position in southwest Missouri, highlighting Missouri’s pivotal role in the conflict.
• 1873: The Missouri, Kansas, and Texas Railway (Katy Railroad) expanded its network through southwest Missouri around August 22, connecting Springfield to other regions and fostering economic growth in the state.
• 1904: The St. Louis World’s Fair, or Louisiana Purchase Exposition, was ongoing, with August 22 featuring international trade exhibits and cultural performances, reinforcing Missouri’s prominence as a global hub.
• 1967: The St. Louis Cardinals played a significant game against the Chicago Cubs at Busch Stadium on August 22, with Bob Gibson pitching a shutout and Orlando Cepeda hitting a key home run, contributing to their World Series-winning season and reinforcing Missouri’s baseball legacy.