On October 22, the following notable historical events related to Missouri occurred:

• 1806: The Lewis and Clark Expedition, having returned to St. Louis in late September, continued to be celebrated on or around October 22, with local festivities in St. Louis honoring their exploration of the Louisiana Purchase, reinforcing Missouri’s role as a western hub.
• 1856: During the “Bleeding Kansas” conflict, pro-slavery “Border Ruffians” from Missouri were active on or around October 22, crossing into Kansas to intimidate anti-slavery settlers, escalating violence and highlighting Missouri’s role in the slavery debate.
• 1864: During the Civil War, Confederate forces under General Sterling Price were engaged in Price’s Raid in Missouri. On October 22, they clashed with Union forces in skirmishes near Kansas City, as part of their ongoing campaign in the state.
• 1885: The Missouri Botanical Garden in St. Louis hosted a significant public exhibition around October 22, showcasing rare tropical plants and reinforcing its reputation as a leading botanical research center.
• 1933: The Great Depression impacted Missouri, and on or around October 22, New Deal-funded Works Progress Administration projects in Kansas City began constructing public infrastructure, providing jobs and economic relief.
• 2004: The St. Louis Cardinals prepared for the World Series against the Boston Red Sox, with team activities and fan rallies in St. Louis on or around October 22, reinforcing Missouri’s baseball legacy ahead of the series start.