On September 14, the following notable historical events related to Missouri occurred:

• 1806: The Lewis and Clark Expedition was in the St. Louis area on or around September 14, nearing the end of their exploration of the Louisiana Purchase, preparing to return to St. Louis as their final destination, underscoring Missouri’s role as a key hub.
• 1847: Missouri’s Doniphan’s Expedition, led by Colonel Alexander Doniphan, was celebrated in St. Louis around September 14 upon their return from the Mexican-American War, having completed an epic 5,000-mile campaign through the Southwest.
• 1861: During the Civil War, the First Battle of Lexington was intensifying in Missouri. On or around September 14, Confederate forces under Sterling Price continued their siege of Union troops in Lexington, a significant early conflict in the state.
• 1893: The Missouri Pacific Railroad expanded its network through southeast Missouri around September 14, connecting Cape Girardeau to other regions and boosting the state’s economic infrastructure.
• 1925: The Missouri State Fair in Sedalia was ongoing around September 14, showcasing agricultural innovations and drawing thousands, reinforcing Missouri’s rural heritage.
• 2001: The St. Louis Cardinals played a notable game against the Milwaukee Brewers at Busch Stadium on September 14, with Albert Pujols hitting a key home run, contributing to their strong season and Missouri’s baseball legacy, in one of the first games resumed after the 9/11 attacks.

On September 15, the following notable historical events related to Missouri occurred:

• 1806: The Lewis and Clark Expedition was in the St. Louis area on or around September 15, nearing the completion of their exploration of the Louisiana Purchase, with St. Louis as their final destination, reinforcing Missouri’s role as a key hub.
• 1856: During the “Bleeding Kansas” conflict, pro-slavery “Border Ruffians” from Missouri were active on or around September 15, crossing into Kansas to disrupt anti-slavery efforts, escalating violence and highlighting Missouri’s role in the slavery debate.
• 1861: During the Civil War, the First Battle of Lexington was ongoing in Missouri. On or around September 15, Confederate forces under Sterling Price intensified their siege of Union troops in Lexington, a critical early conflict in the state.
• 1880: The St. Louis-based Anheuser-Busch brewery began experimenting with refrigerated shipping techniques around September 15, enabling national distribution of Budweiser and solidifying Missouri’s prominence in the brewing industry.
• 1935: The Great Depression impacted Missouri, and on or around September 15, New Deal-funded Works Progress Administration projects in Kansas City began constructing public buildings, providing jobs and boosting the local economy.
• 2004: The St. Louis Cardinals played a significant game against the Houston Astros at Busch Stadium on September 15, with Albert Pujols hitting a game-winning home run, contributing to their strong season and Missouri’s baseball legacy.

On September 16, the following notable historical events related to Missouri occurred:

• 1806: The Lewis and Clark Expedition was in the St. Louis area on or around September 16, nearing the end of their exploration of the Louisiana Purchase, preparing to return to St. Louis, which served as their final destination and a key hub.
• 1846: Missouri volunteers for the Mexican-American War, including the First Missouri Mounted Volunteers under Alexander Doniphan, were departing St. Louis around September 16, heading for their campaign in the Southwest.
• 1861: During the Civil War, the First Battle of Lexington was intensifying in Missouri. On or around September 16, Confederate forces under Sterling Price continued their siege of Union troops in Lexington, a significant early conflict in the state.
• 1895: The Missouri Botanical Garden in St. Louis hosted a major public exhibition around September 16, showcasing rare plant species and reinforcing its reputation as a leading botanical research center.
• 1920: The Kansas City Stockyards processed a record number of livestock around September 16, underscoring Kansas City’s role as a major agricultural hub and boosting Missouri’s economy.
• 1998: The St. Louis Cardinals played a notable game against the Pittsburgh Pirates at Busch Stadium on September 16, with Mark McGwire hitting his 67th home run of the season, continuing his record-breaking campaign and cementing Missouri’s baseball legacy.

On September 17, the following notable historical events related to Missouri occurred:

• 1806: The Lewis and Clark Expedition was in the St. Louis area on or around September 17, nearing the completion of their exploration of the Louisiana Purchase, with St. Louis as their final destination, reinforcing Missouri’s role as a central hub.
• 1857: During the prelude to the Civil War, tensions over slavery were high. On or around September 17, a pro-slavery rally in Kansas City drew Missouri “Border Ruffians,” escalating regional conflicts tied to “Bleeding Kansas.”
• 1861: During the Civil War, the First Battle of Lexington was ongoing in Missouri. On September 17, Confederate forces under Sterling Price tightened their siege on Union troops in Lexington, a key early conflict in the state.
• 1888: The Missouri Pacific Railroad completed a significant track expansion through southwest Missouri around September 17, connecting Springfield to other regions and boosting the state’s economic infrastructure.
• 1930: The Missouri State Fair in Sedalia was ongoing around September 17, showcasing agricultural innovations and drawing large crowds, reinforcing Missouri’s rural heritage.
• 2004: The St. Louis Cardinals played a significant game against the Arizona Diamondbacks at Busch Stadium on September 17, with Albert Pujols hitting a crucial home run, contributing to their strong season and Missouri’s baseball legacy.

On September 18, the following notable historical events related to Missouri occurred:

• 1806: The Lewis and Clark Expedition was in the St. Louis area on or around September 18, nearing the end of their exploration of the Louisiana Purchase, preparing to return to St. Louis as their final destination, highlighting Missouri’s role as a key hub.
• 1850: The Fugitive Slave Act, part of the Compromise of 1850, was passed on September 18, impacting Missouri as a slave state. It heightened tensions between pro-slavery and abolitionist groups in St. Louis and other parts of the state.
• 1861: During the Civil War, the First Battle of Lexington was at its peak in Missouri. On September 18, Confederate forces under Sterling Price intensified their siege on Union troops in Lexington, a significant early conflict in the state.
• 1890: The St. Louis-based Anheuser-Busch brewery expanded its bottling operations around September 18, enhancing Budweiser’s national distribution and reinforcing Missouri’s prominence in the brewing industry.
• 1927: The Kansas City Stockyards processed a record number of livestock around September 18, underscoring Kansas City’s role as a major agricultural hub and boosting Missouri’s economy.
• 1998: The St. Louis Cardinals played a notable game against the Milwaukee Brewers at Busch Stadium on September 18, with Mark McGwire hitting his 68th home run of the season, continuing his record-breaking campaign and cementing Missouri’s baseball legacy.

On September 19, the following notable historical events related to Missouri occurred:

• 1806: The Lewis and Clark Expedition was in the St. Louis area on or around September 19, nearing the completion of their exploration of the Louisiana Purchase, with St. Louis as their final destination, reinforcing Missouri’s role as a central hub.
• 1856: During the “Bleeding Kansas” conflict, pro-slavery “Border Ruffians” from Missouri were active on or around September 19, crossing into Kansas to disrupt anti-slavery efforts, escalating violence and highlighting Missouri’s role in the slavery debate.
• 1861: During the Civil War, the First Battle of Lexington was ongoing in Missouri. On September 19, Confederate forces under Sterling Price continued their siege of Union troops in Lexington, a critical early conflict in the state, nearing its climax.
• 1885: The Missouri Botanical Garden in St. Louis hosted a significant public exhibition around September 19, showcasing rare orchids and reinforcing its reputation as a leading botanical research center.
• 1933: The Great Depression impacted Missouri, and on or around September 19, New Deal-funded Works Progress Administration projects began in St. Louis, constructing public infrastructure and providing jobs to alleviate economic hardship.
• 2004: The St. Louis Cardinals played a significant game against the Arizona Diamondbacks at Busch Stadium on September 19, with Albert Pujols hitting a game-winning home run, contributing to their strong season and Missouri’s baseball legacy.

On September 20, the following notable historical events related to Missouri occurred:

• 1806: The Lewis and Clark Expedition was in the St. Louis area on or around September 20, nearing the end of their exploration of the Louisiana Purchase, preparing to return to St. Louis, which served as their final destination and a key hub.
• 1846: Missouri volunteers for the Mexican-American War, including the First Missouri Mounted Volunteers under Alexander Doniphan, were en route from St. Louis around September 20, heading toward their campaign in the Southwest.
• 1861: During the Civil War, the First Battle of Lexington reached its climax in Missouri. On September 20, Confederate forces under Sterling Price captured the Union garrison in Lexington after a prolonged siege, marking a significant Confederate victory in the state.
• 1890: The Missouri Pacific Railroad expanded its network through southeast Missouri around September 20, connecting Cape Girardeau to other regions and boosting the state’s economic infrastructure.
• 1925: The Missouri State Fair in Sedalia was ongoing around September 20, showcasing agricultural innovations and drawing large crowds, reinforcing Missouri’s rural heritage.
• 1998: The St. Louis Cardinals played a notable game against the Milwaukee Brewers at Busch Stadium on September 20, with Mark McGwire hitting his 69th home run of the season, continuing his record-breaking campaign and cementing Missouri’s baseball legacy.