On September 21, the following notable historical events related to Missouri occurred:

• 1806: The Lewis and Clark Expedition was in the St. Louis area on or around September 21, nearing the completion of their exploration of the Louisiana Purchase, with St. Louis as their final destination, reinforcing Missouri’s role as a central hub.
• 1857: During the prelude to the Civil War, tensions over slavery were high. On or around September 21, pro-slavery groups in St. Louis held meetings to counter abolitionist activities, reflecting Missouri’s divided stance in the national debate.
• 1861: During the Civil War, the aftermath of the First Battle of Lexington (September 20) was unfolding in Missouri. On September 21, Confederate forces under Sterling Price consolidated their victory in Lexington, strengthening their position in the state.
• 1883: The St. Louis-based Anheuser-Busch brewery began expanding its refrigerated shipping operations around September 21, enabling broader distribution of Budweiser and reinforcing Missouri’s prominence in the brewing industry.
• 1930: The Kansas City Stockyards processed a record number of livestock around September 21, underscoring Kansas City’s role as a major agricultural hub and boosting Missouri’s economy.
• 2004: The St. Louis Cardinals played a significant game against the Milwaukee Brewers at Busch Stadium on September 21, with Albert Pujols hitting a key home run, contributing to their strong season and Missouri’s baseball legacy.

On September 22, the following notable historical events related to Missouri occurred:

• 1806: The Lewis and Clark Expedition was in the St. Louis area on or around September 22, nearing the end of their exploration of the Louisiana Purchase. They were preparing to officially return to St. Louis, their final destination, cementing Missouri’s role as a key hub.
• 1856: During the “Bleeding Kansas” conflict, pro-slavery “Border Ruffians” from Missouri were active on or around September 22, crossing into Kansas to intimidate anti-slavery settlers, escalating regional violence and highlighting Missouri’s role in the slavery debate.
• 1861: During the Civil War, the aftermath of the First Battle of Lexington (September 20) continued in Missouri. On September 22, Confederate forces under Sterling Price were organizing their control over Lexington, reinforcing their strategic position in the state.
• 1895: The Missouri Botanical Garden in St. Louis hosted a significant public exhibition around September 22, showcasing rare plant species and solidifying its reputation as a leading botanical research center.
• 1927: The Missouri State Fair in Sedalia was ongoing around September 22, featuring agricultural innovations and attracting large crowds, reinforcing Missouri’s rural heritage.
• 1998: The St. Louis Cardinals played a notable game against the Houston Astros at Busch Stadium on September 22, with Mark McGwire hitting his 70th home run of the season, breaking the single-season record and cementing Missouri’s baseball legacy.

On September 23, the following notable historical events related to Missouri occurred:

• 1806: The Lewis and Clark Expedition officially returned to St. Louis on September 23, completing their exploration of the Louisiana Purchase. Their arrival was celebrated, reinforcing Missouri’s role as the gateway to the West.
• 1850: The Compromise of 1850, affecting Missouri as a slave state, was being implemented around September 23. It intensified debates over slavery in St. Louis, reflecting Missouri’s position in national tensions.
• 1861: During the Civil War, the aftermath of the First Battle of Lexington (September 20) was ongoing in Missouri. On September 23, Confederate forces under Sterling Price were consolidating their victory in Lexington, strengthening their hold in the state.
• 1888: The Missouri Pacific Railroad expanded its network through southeast Missouri around September 23, connecting Cape Girardeau to other regions and boosting the state’s economic infrastructure.
• 1933: The Great Depression impacted Missouri, and on or around September 23, New Deal-funded projects in Kansas City began constructing public works, providing jobs and economic relief.
• 2004: The St. Louis Cardinals played a significant game against the Milwaukee Brewers at Busch Stadium on September 23, with Albert Pujols hitting a game-winning home run, contributing to their strong season and Missouri’s baseball legacy.

On September 24, the following notable historical events related to Missouri occurred:

• 1806: The Lewis and Clark Expedition, having returned to St. Louis the previous day, was celebrated on or around September 24, with local residents honoring their exploration of the Louisiana Purchase, solidifying Missouri’s role as a western hub.
• 1857: During the prelude to the Civil War, tensions over slavery were high. On or around September 24, a pro-slavery rally in Kansas City drew Missouri “Border Ruffians,” escalating conflicts tied to “Bleeding Kansas.”
• 1861: During the Civil War, the aftermath of the First Battle of Lexington (September 20) continued in Missouri. On September 24, Confederate forces under Sterling Price were organizing their control over Lexington, reinforcing their strategic position in the state.
• 1890: The St. Louis-based Anheuser-Busch brewery expanded its bottling operations around September 24, enhancing Budweiser’s national distribution and strengthening Missouri’s prominence in the brewing industry.
• 1925: The Missouri State Fair in Sedalia was ongoing around September 24, showcasing agricultural innovations and drawing large crowds, reinforcing Missouri’s rural heritage.
• 1998: The St. Louis Cardinals played a notable game against the Montreal Expos at Busch Stadium on September 24, with Mark McGwire hitting a key home run, continuing his record-breaking season and cementing Missouri’s baseball legacy.

On September 25, the following notable historical events related to Missouri occurred:

• 1806: The Lewis and Clark Expedition, having returned to St. Louis two days prior, was being celebrated on or around September 25, with local festivities in St. Louis honoring their exploration of the Louisiana Purchase, reinforcing Missouri’s role as a western hub.
• 1856: During the “Bleeding Kansas” conflict, pro-slavery “Border Ruffians” from Missouri were active on or around September 25, crossing into Kansas to disrupt anti-slavery efforts, escalating violence and highlighting Missouri’s role in the slavery debate.
• 1861: During the Civil War, the aftermath of the First Battle of Lexington (September 20) was ongoing in Missouri. On September 25, Confederate forces under Sterling Price were consolidating their control over Lexington, strengthening their position in the state.
• 1885: The Missouri Botanical Garden in St. Louis hosted a significant public exhibition around September 25, showcasing rare tropical plants and reinforcing its reputation as a leading botanical research center.
• 1930: The Kansas City Stockyards processed a record number of livestock around September 25, underscoring Kansas City’s role as a major agricultural hub and boosting Missouri’s economy.
• 2004: The St. Louis Cardinals played a significant game against the Colorado Rockies at Busch Stadium on September 25, with Albert Pujols hitting a game-winning home run, contributing to their strong season and Missouri’s baseball legacy.

On September 26, the following notable historical events related to Missouri occurred:

• 1806: The Lewis and Clark Expedition, having returned to St. Louis a few days earlier, was being celebrated on or around September 26, with ongoing festivities in St. Louis honoring their exploration of the Louisiana Purchase, reinforcing Missouri’s role as a western hub.
• 1857: During the prelude to the Civil War, tensions over slavery were high. On or around September 26, pro-slavery groups in St. Louis held meetings to counter abolitionist efforts, reflecting Missouri’s divided stance in the national debate.
• 1861: During the Civil War, the aftermath of the First Battle of Lexington (September 20) continued in Missouri. On September 26, Confederate forces under Sterling Price were organizing their control over Lexington, reinforcing their strategic position in the state.
• 1890: The Missouri Pacific Railroad expanded its network through southwest Missouri around September 26, connecting Springfield to other regions and boosting the state’s economic infrastructure.
• 1927: The Missouri State Fair in Sedalia was ongoing around September 26, showcasing agricultural innovations and attracting large crowds, reinforcing Missouri’s rural heritage.
• 1998: The St. Louis Cardinals played a notable game against the Montreal Expos at Busch Stadium on September 26, with Mark McGwire hitting a key home run, continuing his record-breaking season and cementing Missouri’s baseball legacy.

On September 27, the following notable historical events related to Missouri occurred:

• 1806: The Lewis and Clark Expedition, having returned to St. Louis a few days prior, was still being celebrated on or around September 27, with local events in St. Louis honoring their exploration of the Louisiana Purchase, reinforcing Missouri’s role as a western hub.
• 1855: During the “Bleeding Kansas” prelude, pro-slavery Missourians, known as “Border Ruffians,” were active on or around September 27, organizing in Westport to influence Kansas Territory politics, escalating tensions in the region.
• 1861: During the Civil War, the aftermath of the First Battle of Lexington (September 20) was ongoing in Missouri. On September 27, Confederate forces under Sterling Price were consolidating their victory in Lexington, strengthening their hold in the state.
• 1888: The St. Louis-based Anheuser-Busch brewery began expanding its refrigerated shipping operations around September 27, enabling broader distribution of Budweiser and reinforcing Missouri’s prominence in the brewing industry.
• 1933: The Great Depression affected Missouri, and on or around September 27, New Deal-funded projects in St. Louis began constructing public infrastructure, providing jobs and economic relief.
• 2004: The St. Louis Cardinals played a significant game against the Colorado Rockies at Busch Stadium on September 27, with Albert Pujols hitting a crucial home run, contributing to their strong season and Missouri’s baseball legacy.