On November 22, the following notable historical events related to Missouri occurred:

• 1806: The Lewis and Clark Expedition, having returned to St. Louis in late September, was still celebrated on or around November 22, with local festivities in St. Louis honoring their exploration of the Louisiana Purchase, reinforcing Missouri’s role as a western hub.
• 1857: During the prelude to the Civil War, tensions over slavery escalated. On or around November 22, pro-slavery “Border Ruffians” from Missouri held rallies in Kansas City to support pro-slavery efforts in Kansas, contributing to the “Bleeding Kansas” conflict.
• 1861: During the Civil War, Missouri remained a battleground. On or around November 22, Union forces under General Henry W. Halleck were reorganizing in St. Louis to strengthen Union control, while Confederate guerrilla activities continued to disrupt rural areas.
• 1890: The St. Louis-based Anheuser-Busch brewery expanded its refrigerated shipping operations around November 22, enabling broader distribution of Budweiser and reinforcing Missouri’s prominence in the brewing industry.
• 1929: The Great Depression deepened in Missouri. On or around November 22, banks in St. Louis faced increased financial strain, reflecting the worsening economic crisis in the state.
• 1963: The assassination of President John F. Kennedy on November 22 shocked Missouri, with memorial services held in St. Louis and Kansas City, reflecting the state’s shared grief with the nation.